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7 papers · 1 filter
Inverse Ising inference with correlated samples
Benedikt Obermayer, Erel Levine
Correlations between two variables of a high-dimensional system can be indicative of an underlying interaction, but can also result from indirect effects. Inverse Ising inference i…
Multifarious Assembly Mixtures: Systems Allowing Retrieval of Diverse Stored Structures
Arvind Murugan, Zorana Zeravcic, Michael P. Brenner +1
Self-assembly materials are traditionally designed so that molecular or meso-scale components form a single kind of large structure. Here, we propose a scheme to create "multifario…
The impact of macroscopic epistasis on long-term evolutionary dynamics
Benjamin H. Good, Michael M. Desai
Genetic interactions can strongly influence the fitness effects of individual mutations, yet the impact of these epistatic interactions on evolutionary dynamics remains poorly unde…
Deleterious passengers in adapting populations
Benjamin H Good, Michael M Desai
Most new mutations are deleterious and are eventually eliminated by natural selection. But in an adapting population, the rapid amplification of beneficial mutations can hinder the…
Protein sectors: statistical coupling analysis versus conservation
Tiberiu Tesileanu, Lucy J. Colwell, Stanislas Leibler
Statistical coupling analysis (SCA) is a method for analyzing multiple sequence alignments that was used to identify groups of coevolving residues termed "sectors". The method appl…
Evolution of bow-tie architectures in biology
Tamar Friedlander, Avraham E. Mayo, Tsvi Tlusty +1
Bow-tie or hourglass structure is a common architectural feature found in biological and technological networks. A bow-tie in a multi-layered structure occurs when intermediate lay…