811 citations · 6.8k across the 93 of their papers we have counts for
95 papers
Variability in the local and global composition of human T-cell receptor repertoires during thymic development across cell types and individuals
Giulio Isacchini, Valentin Quiniou, Hélène Vantomme +6
The adaptive immune response relies on T cells that combine phenotypic specialization with diversity of T cell receptors (TCRs) to recognize a wide range of pathogens. TCRs are acq…
Bayesian estimation of the Kullback-Leibler divergence for categorical sytems using mixtures of Dirichlet priors
Francesco Camaglia, Ilya Nemenman, Thierry Mora +1
In many applications in biology, engineering and economics, identifying similarities and differences between distributions of data from complex processes requires comparing finite…
A quantitative theory of viral-immune coevolution is within reach
Thierry Mora, Aleksandra Walczak
Pathogens drive changes in host immune systems that in turn exert pressure for pathogens to evolve. Quantifying and understanding this constant coevolutionary process has clear pra…
Evolutionary stability of antigenically escaping viruses
Victor Chardès, Andrea Mazzolini, Thierry Mora +1
Antigenic variation is the main immune escape mechanism for RNA viruses like influenza or SARS-CoV-2. While high mutation rates promote antigenic escape, they also induce large mut…
Towards a quantitative theory of tolerance
Thierry Mora, Aleksandra M. Walczak
A cornerstone of the classical view of tolerance is the elimination of self-reactive T cells during negative selection in the thymus. However, high-throughput T-cell receptor seque…
Dynamical information synergy in biochemical signaling networks
Lauritz Hahn, Aleksandra M. Walczak, Thierry Mora
Biological cells encode information about their environment through biochemical signaling networks that control their internal state and response. This information is often encoded…