811 citations · 6.8k across the 93 of their papers we have counts for
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Variability in the local and global composition of human T-cell receptor repertoires during thymic development across cell types and individuals
Giulio Isacchini, Valentin Quiniou, Hélène Vantomme +6
The adaptive immune response relies on T cells that combine phenotypic specialization with diversity of T cell receptors (TCRs) to recognize a wide range of pathogens. TCRs are acq…
Building general Langevin models from discrete data sets
Federica Ferretti, Victor Chardès, Thierry Mora +2
Many living and complex systems exhibit second order emergent dynamics. Limited experimental access to the configurational degrees of freedom results in data that appears to be gen…
Inferring the immune response from repertoire sequencing
Maximilian Puelma Touzel, Aleksandra M. Walczak, Thierry Mora
High-throughput sequencing of B- and T-cell receptors makes it possible to track immune repertoires across time, in different tissues, and in acute and chronic diseases or in healt…
On generative models of T-cell receptor sequences
Giulio Isacchini, Zachary Sethna, Yuval Elhanati +3
T-cell receptors (TCR) are key proteins of the adaptive immune system, generated randomly in each individual, whose diversity underlies our ability to recognize infections and mali…
Quantitative Immunology for Physicists
Grégoire Altan-Bonnet, Thierry Mora, Aleksandra M. Walczak
The adaptive immune system is a dynamical, self-organized multiscale system that protects vertebrates from both pathogens and internal irregularities, such as tumours. For these re…
Measuring the sequence-affinity landscape of antibodies with massively parallel titration curves
Rhys M. Adams, Thierry Mora, Aleksandra M. Walczak +1
Despite the central role that antibodies play in the adaptive immune system and in biotechnology, much remains unknown about the quantitative relationship between an antibody's ami…