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Optimizing information flow in small genetic networks. II: Feed forward interactions
Aleksandra M. Walczak, Gapser Tkacik, William Bialek
Central to the functioning of a living cell is its ability to control the readout or expression of information encoded in the genome. In many cases, a single transcription factor p…
Maximum entropy models for antibody diversity
Thierry Mora, Aleksandra Walczak, William Bialek +1
Recognition of pathogens relies on families of proteins showing great diversity. Here we construct maximum entropy models of the sequence repertoire, building on recent experiments…
Spectral solutions to stochastic models of gene expression with bursts and regulation
Andrew Mugler, Aleksandra M. Walczak, Chris H. Wiggins
Signal-processing molecules inside cells are often present at low copy number, which necessitates probabilistic models to account for intrinsic noise. Probability distributions hav…
Optimizing information flow in small genetic networks. I
Gasper Tkacik, Aleksandra M. Walczak, William Bialek
In order to survive, reproduce and (in multicellular organisms) differentiate, cells must control the concentrations of the myriad different proteins that are encoded in the genome…