125 citations · 129 across the 3 of their papers we have counts for
3 papers
Tranception: protein fitness prediction with autoregressive transformers and inference-time retrieval
Pascal Notin, Mafalda Dias, Jonathan Frazer +4
The ability to accurately model the fitness landscape of protein sequences is critical to a wide range of applications, from quantifying the effects of human variants on disease li…
Deep generative models of genetic variation capture mutation effects
Adam J. Riesselman, John B. Ingraham, Debora S. Marks
The functions of proteins and RNAs are determined by a myriad of interactions between their constituent residues, but most quantitative models of how molecular phenotype depends on…
Genetic variation in human drug-related genes
Charlotta P. I. Schärfe, Roman Tremmel, Matthias Schwab +2
Variability in drug efficacy and adverse effects are observed in clinical practice. While the extent of genetic variability in classical pharmacokinetic genes is rather well unders…