1.6k citations · 3.3k across the 12 of their papers we have counts for
Showing 2015Show all
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q-bio.BM2015★ 906 cited
Quantification of the effect of mutations using a global probability model of natural sequence variation
Thomas A. Hopf, John B. Ingraham, Frank J. Poelwijk +3
Modern biomedicine is challenged to predict the effects of genetic variation. Systematic functional assays of point mutants of proteins have provided valuable empirical information…
q-bio.BM2015
3D RNA and functional interactions from evolutionary couplings
Caleb Weinreb, Adam J. Riesselman, John B. Ingraham +3
Non-coding RNAs are ubiquitous, but the discovery of new RNA gene sequences far outpaces research on their structure and functional interactions. We mine the evolutionary sequence…