1.6k citations · 3.3k across the 12 of their papers we have counts for
4 papers · 1 filter
Quantification of the effect of mutations using a global probability model of natural sequence variation
Thomas A. Hopf, John B. Ingraham, Frank J. Poelwijk +3
Modern biomedicine is challenged to predict the effects of genetic variation. Systematic functional assays of point mutants of proteins have provided valuable empirical information…
3D RNA and functional interactions from evolutionary couplings
Caleb Weinreb, Adam J. Riesselman, John B. Ingraham +3
Non-coding RNAs are ubiquitous, but the discovery of new RNA gene sequences far outpaces research on their structure and functional interactions. We mine the evolutionary sequence…
Sequence co-evolution gives 3D contacts and structures of protein complexes
Thomas A. Hopf, Charlotta P. I. Schärfe, João P. G. L. M. Rodrigues +4
Protein-protein interactions are fundamental to many biological processes. Experimental screens have identified tens of thousands of interactions and structural biology has provide…
3D Protein Structure Predicted from Sequence
Debora S. Marks, Lucy J. Colwell, Robert Sheridan +4
The evolutionary trajectory of a protein through sequence space is constrained by function and three-dimensional (3D) structure. Residues in spatial proximity tend to co-evolve, ye…