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- Harvard UniversityUS12 papers
- Institute for Advanced StudyUS6 papers
- Centre National de la Recherche ScientifiqueFR4 papers
- Laboratoire de Physique ThéoriqueFR3 papers
- University of PennsylvaniaUS3 papers
- Princeton UniversityUS2 papers
- University of WaterlooCA2 papers
- Cancer Genetics (United States)US1 paper
- Cancer Research UKGB1 paper
- Cancer Research UK Cambridge CenterGB1 paper
- Columbia UniversityUS1 paper
- General Department of Preventive MedicineVN1 paper
5 papers · 1 filter
Theory of spike timing based neural classifiers
Ran Rubin, Remi Monasson, Haim Sompolinsky
We study the computational capacity of a model neuron, the Tempotron, which classifies sequences of spikes by linear-threshold operations. We use statistical mechanics and extreme…
Mapping Dynamic Histone Acetylation Patterns to Gene Expression in Nanog-depleted Murine Embryonic Stem Cells
Florian Markowetz, Klaas W Mulder, Edoardo M Airoldi +2
Embryonic stem cells (ESC) have the potential to self-renew indefinitely and to differentiate into any of the three germ layers. The molecular mechanisms for self-renewal, maintena…
The Structure of Genealogies in the Presence of Purifying Selection: A "Fitness-Class Coalescent"
Aleksandra M. Walczak, Lauren E. Nicolaisen, Joshua B. Plotkin +1
Compared to a neutral model, purifying selection distorts the structure of genealogies and hence alters the patterns of sampled genetic variation. Although these distortions may be…
The structure of allelic diversity in the presence of purifying selection
Michael M. Desai, Lauren E. Nicolaisen, Aleksandra M. Walczak +1
In the absence of selection, the structure of allelic diversity is described by the elegant sampling formula of Ewens. This formula has helped shape our expectations of empirical p…
Higher Order Boolean networks as models of cell state dynamics
Elke K. Markert, Nils Baas, Arnold J. Levine +1
The regulation of the cell state is a complex process involving several components. These complex dynamics can be modeled using Boolean networks, allowing us to explain the existen…