374 citations · 1.7k across the 55 of their papers we have counts for
4 papers · 1 filter
Ripping RNA by Force using Gaussian Network Models
Changbong Hyeon, D. Thirumalai
Using force as a probe to map the folding landscapes of RNA molecules has become a reality thanks to major advances in single molecule pulling experiments. Although the unfolding p…
Protein Collapse is Encoded in the Folded State Architecture
Himadri S. Samanta, Pavel I. Zhuravlev, Michael Hinczewski +3
Natural protein sequences that self-assemble to form globular structures are compact with high packing densities in the folded states. It is known that proteins unfold upon additio…
Noise control in gene regulatory networks with negative feedback
Michael Hinczewski, D. Thirumalai
Genes and proteins regulate cellular functions through complex circuits of biochemical reactions. Fluctuations in the components of these regulatory networks result in noise that i…
Phenomenological and microscopic theories for catch bonds
Shaon Chakrabarti, Michael Hinczewski, D. Thirumalai
Lifetimes of bound states of protein complexes or biomolecule folded states typically decrease when subject to mechanical force. However, a plethora of biological systems exhibit t…