264 citations · 2.7k across the 64 of their papers we have counts for
64 papers
Scaling regimes for wormlike chains confined to cylindrical surfaces under tension
Greg Morrison, D. Thirumalai
We compute the free energy of confinement for a wormlike chain (WLC), with persistence length , that is confined to the surface of a cylinder of radius under a…
On the emergence of orientational order in folded proteins with implications for allostery
Debayan Chakraborty, Mauro Lorenzo Mugnai, D. Thirumalai
The beautiful structures of single and multi-domain proteins are clearly ordered in some fashion but cannot be readily classified using group theory methods that are successfully u…
Theory and simulations for crowding-induced changes in stability of proteins with applications to repressor
Natalia D. Denesyuk, D. Thirumalai
Experiments and theories have shown that when steric interactions between crowding particles and proteins are dominant, which give rise to Asakura-Oosawa depletion forces, then the…
Iterative Annealing Mechanism Explains the Functions of the GroEL and RNA Chaperones
D. Thirumalai, George H. Lorimer, Changbong Hyeon
Molecular chaperones are ATP-consuming biological machines, which facilitate the folding of proteins and RNA molecules that are kinetically trapped in misfolded states for long tim…
Theoretical Perspectives on Biological Machines
Mauro L. Mugnai, Changbong Hyeon, Michael Hinczewski +1
Many biological functions are executed by molecular machines, which consume energy and convert it into mechanical work. Biological machines have evolved to transport cargo, facilit…
Symmetry, Rigidity, and Allosteric Signaling: From Monomeric Proteins to Molecular Machines
D. Thirumalai, Changbong Hyeon, Pavel I. Zhuravlev +1
Allosteric signaling in biological molecules, which may be viewed as specific action at a distance due to localized perturbation upon binding of ligands or changes in environmental…