100 citations · 292 across the 14 of their papers we have counts for
14 papers
A mathematical model for phenotypic heterogeneity in breast cancer with implications for therapeutic strategies
Xin Li, D. Thirumalai
Inevitably, almost all cancer patients develop resistance to targeted therapy. Intratumor heterogeneity (ITH) is a major cause of drug resistance. Mathematical models that explain…
Self-generated persistent random forces drive phase separation in growing tumors
Sumit Sinha, D. Thirumalai
A single solid tumor, composed of nearly identical cells, exhibits heterogeneous dynamics. Cells dynamics in the core is glass-like whereas those in the periphery undergo diffusive…
From Hi-C Contact Map to Three-dimensional Organization of Interphase Human Chromosomes
Guang Shi, D. Thirumalai
The probability of two loci, separated by a certain genome length, being in contact can be inferred using the Chromosome Conformation Capture (3C) method and related Hi-C experimen…
Far from equilibrium dynamics of tracer particles embedded in a growing multicellular spheroid
Himadri S. Samanta, Sumit Sinha, D. Thirumalai
By embedding inert tracer particles (TPs) in a growing multicellular spheroid the local stresses on the cancer cells (CCs) can be measured. In order for this technique to be effect…
Fragile-to-Strong Crossover, growing length scales, and dynamic heterogeneity in Wigner Glasses
Hyun Woo Cho, Mauro L. Mugnai, T. R. Kirkpatrick +1
Colloidal particles, which are ubiquitous, have become ideal testing grounds for the structural glass transition (SGT) theories. In these systems glassy behavior is manifested as t…
On the origin of super-diffusive behavior in a class of non-equilibrium systems
Himadri S. Samanta, D. Thirumalai
Experiments and simulations have established that dynamics in a class of living and abiotic systems that are far from equilibrium exhibit super diffusive behavior at long times, wh…