202 citations · 360 across the 8 of their papers we have counts for
8 papers
Discrete step sizes of molecular motors lead to bimodal non-Gaussian velocity distributions under force
Huong T. Vu, Shaon Chakrabarti, Michael Hinczewski +1
Fluctuations in the physical properties of biological machines are inextricably linked to their functions. Distributions of run-lengths and velocities of processive molecular motor…
Design principles governing the motility of myosin V
Michael Hinczewski, Riina Tehver, D. Thirumalai
The molecular motor myosin V exhibits a wide repertoire of pathways during the stepping process, which is intimately connected to its biological function. The best understood of th…
Gene Regulation by Riboswitches with and without Negative Feedback Loop
Jong-Chin Lin, D. Thirumalai
Riboswitches, structured elements in the untranslated regions of messenger RNAs, regulate gene expression by binding specific metabolites. We introduce a kinetic network model that…
Molecular origin of constant m-values, denatured state collapse, and residue-dependent transition midpoints in globular proteins
Edward P. O'Brien, Bernard R. Brooks, Dave Thirumalai
Experiments show that for many two state folders the free energy of the native state DG_ND([C]) changes linearly as the denaturant concentration [C] is varied. The slope, m = d DG_…
Finite size effects on thermal denaturation of globular proteins
Mai Suan Li, D. K. Klimov, D. Thirumalai
Finite size effects on the cooperative thermal denaturation of proteins are considered. A dimensionless measure of cooperativity, Omega, scales as N^zeta, where N is the number of…
Kinetic Partitioning Mechanism as a Unifying Theme in the Folding of Biomolecules
D. Thirumalai, D. K. Klimov, S. A. Woodson
We present a unified framework for folding kinetics of proteins and RNA. The basis for this framework relies on the notion of topological frustration, which gives rise to several c…