374 citations · 1.7k across the 55 of their papers we have counts for
5 papers · 1 filter
Force-dependent switch in protein unfolding pathways and transition state movements
Pavel I. Zhuravlev, Michael Hinczewski, Shaon Chakrabarti +2
Although known that single domain proteins fold and unfold by parallel pathways, demonstration of this expectation has been difficult to establish in experiments. Unfolding rate, $…
On the importance of hydrodynamic interactions in the stepping kinetics of kinesin
Yonathan Goldtzvik, Zhechun Zhang, D. Thirumalai
Conventional kinesin walks by a hand-over-hand mechanism on the microtubule (MT) by taking 8 discrete steps, and consumes one ATP molecule per step. The time needed to c…
Dissecting Ubiquitin Folding Using the Self-Organized Polymer Model
Govardhan Reddy, D. Thirumalai
Folding of Ubiquitin (Ub) is investigated at low and neutral pH at different temperatures using simulations of the coarse-grained Self-Organized-Polymer model with side chains. The…
Helicase processivity and not the unwinding velocity exhibits universal increase with force
David L. Pincus, Shaon Chakrabarti, D. Thirumalai
Helicases, involved in a number of cellular functions, are motors that translocate along singlestranded nucleic acid and couple the motion to unwinding double-strands of a duplex n…
Unexpected swelling of stiff DNA in a polydisperse crowded environment
Hongsuk Kang, Ngo Minh Toan, Changbong Hyeon +1
We investigate the conformations of DNA-like stiff chains, characterized by contour length () and persistence length (), in a variety of crowded environments containing mon…