374 citations · 602 across the 9 of their papers we have counts for
4 papers · 1 filter
Crowding Promotes the Switch from Hairpin to Pseudoknot Conformation in Human Telomerase RNA
Natalia A. Denesyuk, D. Thirumalai
Formation of a pseudoknot in the conserved RNA core domain in the ribonucleoprotein human telomerase is required for function. In vitro experiments show that the pseudoknot (PK) is…
Role of water in Protein Aggregation and Amyloid Polymorphism
D. Thirumalai, Govardhan Reddy, John E. Straub
A variety of neurodegenerative diseases are associated with the formation of amyloid plaques. Our incomplete understanding of this process underscores the need to decipher the prin…
Influence of Nanoparticle Size and Shape on Oligomer Formation of an Amyloidogenic Peptide
Edward P. O'Brien, John E. Straub, Bernard R. Brooks +1
Understanding the influence of macromolecular crowding and nanoparticles on the formation of in-register -sheets, the primary structural component of amyloid fibrils, is a first…
Polyelectrolyte and polyampholyte effects in synthetic and biological macromolecules
Ngo Minh Toan, Bae-Yeun Ha, D. Thirumalai
The nature of electrostatic interactions involving polyanions modulate the properties of both synthetic and biological macromolecules. Although intensely studied for decades the in…