output
19982025
most citedSecond-generation PLINK: rising to the challenge of larger and richer datasets

14.3k citations

Showing 2018Show all

10 papers · 1 filter

cs.CV2018★ 715 cited

BACH: Grand Challenge on Breast Cancer Histology Images

Guilherme Aresta, Teresa Araújo, Scotty Kwok +33

Breast cancer is the most common invasive cancer in women, affecting more than 10% of women worldwide. Microscopic analysis of a biopsy remains one of the most important methods to…

cs.CV2018★ 1.7k cited

Confounding variables can degrade generalization performance of radiological deep learning models

John R. Zech, Marcus A. Badgeley, Manway Liu +3

Early results in using convolutional neural networks (CNNs) on x-rays to diagnose disease have been promising, but it has not yet been shown that models trained on x-rays from one…

q-bio.GN2018★ 3 cited

Insights into Complex Brain Functions Related to Schizophrenia Disorder through Causal Network Analysis

Akram Yazdani, Raul Mendez Giraldez, Ahmad Samiei

Gene expression represents a fundamental interface between genes and environment in the development and ongoing plasticity of the human organism. Individual differences in gene exp…

q-bio.QM2018★ 6 cited

Quantifying the Sensitivity of HIV-1 Viral Entry to Receptor and Coreceptor Expression

Bhaven Mistry, Maria R. D'Orsogna, Nicholas E. Webb +2

Infection by many viruses begins with fusion of viral and cellular lipid membranes, followed by entry of viral contents into the target cell and ultimately, after many biochemical…

q-bio.QM2018

Model-based clustering of multi-tissue gene expression data

Pau Erola, Johan LM Björkegren, Tom Michoel

Recently, it has become feasible to generate large-scale, multi-tissue gene expression data, where expression profiles are obtained from multiple tissues or organs sampled from doz…

cs.CL2018★ 20 cited

Exploiting Task-Oriented Resources to Learn Word Embeddings for Clinical Abbreviation Expansion

Yue Liu, Tao Ge, Kusum S. Mathews +2

In the medical domain, identifying and expanding abbreviations in clinical texts is a vital task for both better human and machine understanding. It is a challenging task because m…

cs.CY2018★ 5 cited

Processing of Electronic Health Records using Deep Learning: A review

Venet Osmani, Li Li, Matteo Danieletto +3

Availability of large amount of clinical data is opening up new research avenues in a number of fields. An exciting field in this respect is healthcare, where secondary use of heal…

cs.CV2018★ 9 cited

Adversarial Image Registration with Application for MR and TRUS Image Fusion

Pingkun Yan, Sheng Xu, Ardeshir R. Rastinehad +1

Robust and accurate alignment of multimodal medical images is a very challenging task, which however is very useful for many clinical applications. For example, magnetic resonance…

q-bio.PE2018

Fierce selection and interference in B-cell repertoire response to chronic HIV-1

Armita Nourmohammad, Jakub Otwinowski, Marta Łuksza +2

During chronic infection, HIV-1 engages in a rapid coevolutionary arms race with the host's adaptive immune system. While it is clear that HIV exerts strong selection on the adapti…

stat.ML2018★ 24 cited

Tournament Leave-pair-out Cross-validation for Receiver Operating Characteristic (ROC) Analysis

Ileana Montoya Perez, Antti Airola, Peter J. Boström +2

Receiver operating characteristic (ROC) analysis is widely used for evaluating diagnostic systems. Recent studies have shown that estimating an area under ROC curve (AUC) with stan…