output
19982025
most citedSecond-generation PLINK: rising to the challenge of larger and richer datasets

14.3k citations

Showing 2020Show all

8 papers · 1 filter

eess.IV2020★ 6 cited

Automatic Brain Tumor Segmentation with Scale Attention Network

Yading Yuan

Automatic segmentation of brain tumors is an essential but challenging step for extracting quantitative imaging biomarkers for accurate tumor detection, diagnosis, prognosis, treat…

stat.AP2020

GEE-TGDR: A longitudinal feature selection algorithm and its application to lncRNA expression profiles for psoriasis patients treated with immune therapies

Suyan Tian, Chi Wang, Mayte Suarez-Farinas

With the fast evolution of high-throughput technology, longitudinal gene expression experiments have become affordable and increasingly common in biomedical fields. Generalized est…

stat.ME2020★ 1 cited

Estimation of causal effects of multiple treatments in healthcare database studies with rare outcomes

Liangyuan Hu, Chenyang Gu

The preponderance of large-scale healthcare databases provide abundant opportunities for comparative effectiveness research. Evidence necessary to making informed treatment decisio…

stat.AP2020★ 78 cited

Estimating heterogeneous survival treatment effect in observational data using machine learning

Liangyuan Hu, Jiayi Ji, Fan Li

Methods for estimating heterogeneous treatment effect in observational data have largely focused on continuous or binary outcomes, and have been relatively less vetted with surviva…

q-bio.MN2020★ 3 cited

Exact Parallelization of the Stochastic Simulation Algorithm for Scalable Simulation of Large Biochemical Networks

Arthur P. Goldberg, David R. Jefferson, John A. P. Sekar +1

Comprehensive simulations of the entire biochemistry of cells have great potential to help physicians treat disease and help engineers design biological machines. But such simulati…

cs.DB2020★ 2 cited

ObjTables: structured spreadsheets that promote data quality, reuse, and integration

Jonathan R. Karr, Wolfram Liebermeister, Arthur P. Goldberg +2

A central challenge in science is to understand how systems behaviors emerge from complex networks. This often requires aggregating, reusing, and integrating heterogeneous informat…

q-bio.QM2020★ 210 cited

Deep Representation Learning of Electronic Health Records to Unlock Patient Stratification at Scale

Isotta Landi, Benjamin S. Glicksberg, Hao-Chih Lee +6

Deriving disease subtypes from electronic health records (EHRs) can guide next-generation personalized medicine. However, challenges in summarizing and representing patient data pr…

stat.ME2020★ 78 cited

Directed Acyclic Graphs and causal thinking in clinical risk prediction modeling

Marco Piccininni, Stefan Konigorski, Jessica L Rohmann +1

Background: In epidemiology, causal inference and prediction modeling methodologies have been historically distinct. Directed Acyclic Graphs (DAGs) are used to model a priori causa…