811 citations · 7.3k across the 89 of their papers we have counts for
12 papers · 1 filter
Cost and benefits of CRISPR spacer acquisition
Serena Bradde, Thierry Mora, Aleksandra M. Walczak
CRISPR-Cas mediated immunity in bacteria allows bacterial populations to protect themselves against pathogens. However, it also exposes them to the dangers of auto-immunity by deve…
Receptor crosstalk improves concentration sensing of multiple ligands
Martin Carballo-Pacheco, Jonathan Desponds, Tatyana Gavrilchenko +5
Cells need to reliably sense external ligand concentrations to achieve various biological functions such as chemotaxis or signaling. The molecular recognition of ligands by surface…
Detecting T-cell receptors involved in immune responses from single repertoire snapshots
Mikhail V Pogorelyy, Anastasia A Minervina, Mikhail Shugay +4
Hypervariable T-cell receptors (TCR) play a key role in adaptive immunity, recognising a vast diversity of pathogen-derived antigens. High throughput sequencing of TCR repertoires…
OLGA: fast computation of generation probabilities of B- and T-cell receptor amino acid sequences and motifs
Zachary Sethna, Yuval Elhanati, Curtis G. Callan +2
Motivation: High-throughput sequencing of large immune repertoires has enabled the development of methods to predict the probability of generation by V(D)J recombination of T- and…
Modeling the correlated activity of neural populations: A review
Christophe Gardella, Olivier Marre, Thierry Mora
The principles of neural encoding and computations are inherently collective and usually involve large populations of interacting neurons with highly correlated activities. While t…
Genesis of the alpha beta T-cell receptor
Thomas Dupic, Quentin Marcou, Aleksandra M. Walczak +1
The T-cell (TCR) repertoire relies on the diversity of receptors composed of two chains, called and , to recognize pathogens. Using results of high throughput sequencing and…