Binding of Curvature-Inducing Proteins onto Biomembranes

Abstract

We review the theoretical analyses and simulations of the interactions between curvature-inducing proteins and biomembranes. Laterally isotropic proteins induce spherical budding, whereas anisotropic proteins, such as Bin/Amphiphysin/Rvs (BAR) superfamily proteins, induce tabulation. Both types of proteins can sense the membrane curvature. We describe the theoretical analyses of various transitions of protein binding accompanied by a change in various properties, such as the number of buds, the radius of membrane tubes, and the nematic order of anisotropic proteins. Moreover, we explain the membrane-mediated interactions and protein assembly. Many types of membrane shape transformations (spontaneous tubulation, formation of polyhedral vesicles, polygonal tubes, periodic bumps, and network structures, etc.) have been demonstrated by coarse-grained simulations. Furthermore, traveling waves and Turing patterns under the coupling of reaction-diffusion dynamics and membrane deformation are described.

19 pages, 17 figures (Figures 4c, d are corrected in ver. 3)

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Cited by in corpus (9)

• Membrane shape deformation induced by curvature-inducing proteins consisting of chiral crescent binding and intrinsically disordered domains
• Excitable reaction-diffusion waves of curvature-inducing proteins on deformable membrane tubes
• Nonequilibrium Membrane Dynamics Induced by Active Protein Interactions and Chemical Reactions: A Review
• Membrane domain formation induced by binding/unbinding of curvature-inducing molecules onto both membrane surfaces
• Curvature-sensing and generation by membrane proteins: a review
• Estimation of anisotropic bending rigidities and spontaneous curvatures of crescent curvature-inducing proteins from tethered-vesicle experimental data
• Curvature sensing of curvature-inducing proteins with internal structure
• Spatiotemporal pattern formation of membranes induced by surface molecular binding/unbinding
• Growth and shrinkage of tissue sheets on substrates: buds, buckles, and pores