Spatiotemporal pattern formation of membranes induced by surface molecular binding/unbinding
arXiv:2410.23635 · doi:10.1039/d4sm01277a
Abstract
Nonequilibrium membrane pattern formation is studied using meshless membrane simulation. We consider that molecules bind to either surface of a bilayer membrane and move to the opposite leaflet by flip--flop. When binding does not modify the membrane properties and the transfer rates among the three states are cyclically symmetric, the membrane exhibits spiral-wave and homogeneous-cycling modes at high and low binding rates, respectively, as in an off-lattice cyclic Potts model. When binding changes the membrane spontaneous curvature, these spatiotemporal dynamics are coupled with microphase separation. When two symmetric membrane surfaces are in thermal equilibrium, the membrane domains form 4.8.8 tiling patterns in addition to stripe and spot patterns. In nonequilibrium conditions, moving biphasic domains and time-irreversible fluctuating patterns appear. The domains move ballistically or diffusively depending on the conditions.
10 pages, 11 figures
References in corpus (20)
- Membrane simulation models from nm to m scale
- Membrane tubule formation by banana-shaped proteins with or without transient network structure
- Measurement of the bending rigidity and spontaneous curvature of fluid membranes in simulations
- Solvent-free coarse-grained lipid model for large-scale simulations
- Pattern Formation in Reaction-Diffusion System on Membrane with Mechanochemical Feedback
- Reaction-Diffusion Waves Coupled with Membrane Curvature
- Structure formation in binary mixtures of surfactants: vesicle opening-up to bicelles and octopus-like micelles
- Membrane shape deformation induced by curvature-inducing proteins consisting of chiral crescent binding and intrinsically disordered domains
- Cup-to-vesicle transition of a fluid membrane with spontaneous curvature
- Line tension of branching junctions of bilayer membranes
- Binding of Curvature-Inducing Proteins onto Biomembranes
- Excitable reaction-diffusion waves of curvature-inducing proteins on deformable membrane tubes
- Nonequilibrium Membrane Dynamics Induced by Active Protein Interactions and Chemical Reactions: A Review
- Membrane domain formation induced by binding/unbinding of curvature-inducing molecules onto both membrane surfaces
- Detachment of fluid membrane from substrate and vesiculation
- Cycling and spiral-wave modes in an active cyclic Potts model
- Estimation of anisotropic bending rigidities and spontaneous curvatures of crescent curvature-inducing proteins from tethered-vesicle experimental data
- Spatiotemporal patterns in the active cyclic Potts model
- Spatiotemporal Patterns in Active Four-State Potts Models
- Curvature sensing of curvature-inducing proteins with internal structure