Membrane domain formation induced by binding/unbinding of curvature-inducing molecules onto both membrane surfaces

Abstract

The domain formation of curvature-inducing molecules, such as peripheral or transmembrane proteins and conical surfactants, is studied in thermal equilibrium and nonequilibrium steady states using meshless membrane simulations. These molecules can bind onto both surfaces of a bilayer membrane and also move to the opposite leaflet by a flip-flop. In symmetric conditions for the two leaflets, the membrane domains form checkerboard patterns in addition to stripe and spot patterns. The unbound membrane stabilizes the vertices of the checkerboard. In asymmetric conditions, the domains form kagome-lattice and thread-like domains. In the nonequilibrium steady states, a flow of the binding molecules between the upper and lower solutions can occur via the flip-flop.

10 pages, 12 figures

References in corpus (9)

• Two- or three-step assembly of banana-shaped proteins coupled with shape transformation of lipid membranes
• Reaction-Diffusion Waves Coupled with Membrane Curvature
• Binding of thermalized and active membrane curvature-inducing proteins
• Acceleration and suppression of banana-shaped-protein-induced tubulation by addition of small membrane inclusions of isotropic spontaneous curvatures
• Structure formation in binary mixtures of surfactants: vesicle opening-up to bicelles and octopus-like micelles
• Membrane shape deformation induced by curvature-inducing proteins consisting of chiral crescent binding and intrinsically disordered domains
• Vesicle budding induced by binding of curvature-inducing proteins
• Binding of Curvature-Inducing Proteins onto Biomembranes
• Excitable reaction-diffusion waves of curvature-inducing proteins on deformable membrane tubes

Cited by in corpus (6)

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• Cycling and spiral-wave modes in an active cyclic Potts model
• Spatiotemporal patterns in the active cyclic Potts model
• Spatiotemporal Patterns in Active Four-State Potts Models
• Spatiotemporal pattern formation of membranes induced by surface molecular binding/unbinding
• Dynamic modes of active Potts models with factorizable numbers of states