Vesicle budding induced by binding of curvature-inducing proteins

Abstract

Vesicle budding induced by protein binding that generates an isotropic spontaneous curvature is studied using a mean-field theory. Many spherical buds are formed via protein binding. As the binding chemical potential increases, the proteins first bind to the buds and then to the remainder of the vesicle. For a high spontaneous curvature and/or high bending rigidity of the bound membrane, it is found that a first-order transition occurs between a small number of large buds and a large number of small buds. These two states coexist around the transition point. The proposed scheme is simple and easily applicable to many interaction types, so we investigate the effects of inter-protein interactions, the protein-insertion-induced changes in area, the variation of the saddle-splay-modulus, and the area-difference-elasticity energy. The differences in the preferred curvatures for curvature sensing and generation are also clarified.

arXiv comment14 pages, 17 figures

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Cited by in corpus (10)

• Binding of anisotropic curvature-inducing proteins onto membrane tubes
• Binding of Curvature-Inducing Proteins onto Biomembranes
• Binding of curvature-inducing proteins onto tethered vesicles
• Excitable reaction-diffusion waves of curvature-inducing proteins on deformable membrane tubes
• Nonequilibrium Membrane Dynamics Induced by Active Protein Interactions and Chemical Reactions: A Review
• Membrane domain formation induced by binding/unbinding of curvature-inducing molecules onto both membrane surfaces
• Curvature-sensing and generation by membrane proteins: a review
• Can biophysical models give insight into the synaptic changes associated with addiction?
• Estimation of anisotropic bending rigidities and spontaneous curvatures of crescent curvature-inducing proteins from tethered-vesicle experimental data
• Curvature sensing of curvature-inducing proteins with internal structure