Membrane mediated aggregation of curvature inducing nematogens and membrane tubulation
arXiv:1302.1641 · doi:10.1016/j.bpj.2012.12.045
Abstract
The shapes of cell membranes are largely regulated by membrane associated, curvature active, proteins. We use a numerical model of the membrane with elongated membrane inclusions, recently developed by us, which posses spontaneous directional curvatures that could be different along and perpendicular to its long axis. We show that, due to membrane mediated interactions these curvature inducing membrane nematogens can oligomerize spontaneously, even at low concentrations, and change the local shape of the membrane. We demonstrate that for a large group of such inclusions, where the two spontaneous curvatures have equal sign, the tubular conformation and sometime the sheet conformation of the membrane are the common equilibrium shapes. We elucidate the factors necessary for the formation of these {\it protein lattices}. Furthermore, the elastic properties of the tubes, like their compressional stiffness and persistence length are calculated. Finally, we discuss the possible role of nematic disclination in capping and branching of the tubular membranes.
arXiv comment15pages, 8 figures
References in corpus (7)
- N-body Study of Anisotropic Membrane Inclusions: Membrane Mediated Interactions and Ordered Aggregation
- Monte Carlo simulations of fluid vesicles with in plane orientational ordering
- On the formation of caveolae and similar membrane invaginations
- Shape Instabilities in the Dynamics of a Two-component Fluid Membrane
- Defects in nematic membranes can buckle into pseudospheres
- Defect generation and deconfinement on corrugated topographies
- Role of disclinations in determining the morphology of deformable fluid interfaces
Cited by in corpus (22)
- Mesoscale computational studies of membrane bilayer remodeling by curvature-inducing proteins
- Membrane tubule formation by banana-shaped proteins with or without transient network structure
- Environmental bias and elastic curves on surfaces
- Two- or three-step assembly of banana-shaped proteins coupled with shape transformation of lipid membranes
- Formation of polyhedral vesicles and polygonal membrane tubes induced by banana-shaped proteins
- Defining the Free-Energy Landscape of Curvature-Inducing Proteins on Membrane Bilayers
- Membrane morphologies induced by arc-shaped scaffolds are determined by arc angle and coverage
- Tubulation pattern of membrane vesicles coated with bio filaments
- Acceleration and suppression of banana-shaped-protein-induced tubulation by addition of small membrane inclusions of isotropic spontaneous curvatures
- Shape deformation of lipid membranes by banana-shaped protein rods: Comparison with isotropic inclusions and membrane rupture
- Binding of anisotropic curvature-inducing proteins onto membrane tubes
- Binding of Curvature-Inducing Proteins onto Biomembranes
- Construction of nuclear envelope shape by a high-genus vesicle with pore-size constraint
- Lipid-protein interaction induced domains: kinetics and conformational changes in multicomponent vesicles
- Curvature-sensing and generation by membrane proteins: a review
- Curvature-driven stability of defects in nematic textures over spherical disks
- Membrane-mediated interactions
- Stability of branched tubular membrane structures
- Renormalized mechanics and stochastic thermodynamics of growing vesicles
- Anisotropic membrane curvature sensing by amphipathic peptides
- Curvature-induced clustering of cell adhesion proteins
- Structural symmetry and membrane curvature sensing