Renormalized mechanics and stochastic thermodynamics of growing vesicles

Abstract

Uncovering the rules governing the nonequilibrium dynamics of the membranes that define biological cells is of central importance to understanding the physics of living systems. We theoretically and computationally investigate the behavior of flexible quasispherical vesicles that exchange membrane constituents, internal volume, and heat with an external reservoir. The excess chemical potential and osmotic pressure difference imposed by the reservoir act as generalized thermodynamic driving forces that modulate vesicle morphology. We show that the renormalization of membrane mechanical properties by nonequilibrium driving gives rise to a morphological transition between a weakly driven regime, in which growing vesicles remain quasispherical, and a strongly driven regime, in which vesicles accommodate rapid membrane uptake by developing surface wrinkles. Additionally, we propose a minimal vesicle growth-shape law, derived using insights from stochastic thermodynamics, that robustly describes vesicle growth dynamics even in strongly driven, far-from-equilibrium regimes.

References in corpus (37)

• Stochastic thermodynamics, fluctuation theorems, and molecular machines
• Dissipation bounds all steady-state current fluctuations
• Sculpting vesicles with active particles: Less is more
• Fluid membranes in hydrodynamic flow fields: Formalism and an application to fluctuating quasi-spherical vesicles in shear flow
• Current fluctuations and transport efficiency for general Langevin systems
• Inferring dissipation from current fluctuations
• Multidimensional thermodynamic uncertainty relations
• Mechanics of active surfaces
• Clustering and heterogeneous dynamics in a kinetic Monte-Carlo model of self-propelled hard disks
• Endocytic proteins drive vesicle growth via instability in high membrane tension environment
• Membrane mediated aggregation of curvature inducing nematogens and membrane tubulation
• Design principles for non-equilibrium self-assembly
• Osmotically Driven Shape Transformations in Axons
• Shape and Displacement Fluctuations in Soft Vesicles Filled by Active Particles
• Active Contact Forces Drive Non-Equilibrium Fluctuations in Membrane Vesicles
• Bulk self-assembly of giant, unilamellar vesicles
• Play. Pause. Rewind. Measuring local entropy production and extractable work in active matter
• Fluctuating shells under pressure
• Variance Sum Rule for Entropy Production
• Robust nonequilibrium pathways to microcompartment assembly
• Direct Route to Thermodynamic Uncertainty Relations and Their Saturation
• The irreversible thermodynamics of curved lipid membranes
• Shape Transformations of Vesicles induced by Swim Pressure
• Particle-based membrane model for mesoscopic simulation of cellular dynamics
• Statistical mechanics of thin spherical shells
• Effective tension and fluctuations in active membranes
• Dynamics of growth and form in prebiotic vesicles
• Deformation of a soft boundary induced and enhanced by enclosed active particles
• Approximating the dynamical evolution of systems of strongly-interacting overdamped particles
• Active Fusion and Fission Processes on a Fluid Membrane
• Computational modeling of active deformable membranes embedded in 3D flows
• Entropy production and thermodynamic inference for stochastic microswimmers
• Collective synchronization of dissipatively-coupled noise-activated processes
• Active buckling of pressurized spherical shells : Monte Carlo Simulation
• Active particles confined in deformable droplets
• Dynamical description of vesicle growth and shape change
• Thermodynamic inference of correlations in nonequilibrium collective dynamics