Theory of nonequilibrium free energy transduction by molecular machines
arXiv:1909.09180 · doi:10.1021/acs.chemrev.9b00254
Abstract
Biomolecular machines are protein complexes that convert between different forms of free energy. They are utilized in nature to accomplish many cellular tasks. As isothermal nonequilibrium stochastic objects at low Reynolds number, they face a distinct set of challenges compared to more familiar human-engineered macroscopic machines. Here we review central questions in their performance as free energy transducers, outline theoretical and modeling approaches to understand these questions, identify both physical limits on their operational characteristics and design principles for improving performance, and discuss emerging areas of research.
arXiv comment90 pages, 17 figures. Accepted version, with figure attribution and copyright statements corrected. This article is in press in Chemical Reviews, available online at https://doi.org/10.1021/acs.chemrev.9b00254
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