141 citations · 294 across the 17 of their papers we have counts for
17 papers
Tube geometry controls protein cluster conformation and stability on the endoplasmic reticulum surface
Liam T Kischuck, Aidan I Brown
The endoplasmic reticulum (ER), a cellular organelle that forms a cell-spanning network of tubes and sheets, is an important location of protein synthesis and folding. When the ER…
Diffusive search and trajectories on spatial networks: a propagator approach
Zubenelgenubi C. Scott, Aidan I. Brown, Saurabh S. Mogre +2
Several organelles in eukaryotic cells, including mitochondria and the endoplasmic reticulum, form interconnected tubule networks extending throughout the cell. These tubular netwo…
Design principles for the glycoprotein quality control pathway
Aidan I Brown, Elena F Koslover
Newly-translated glycoproteins in the endoplasmic reticulum (ER) often undergo cycles of chaperone binding and release in order to assist in folding. Quality control is required to…
Theory of nonequilibrium free energy transduction by molecular machines
Aidan I Brown, David A Sivak
Biomolecular machines are protein complexes that convert between different forms of free energy. They are utilized in nature to accomplish many cellular tasks. As isothermal nonequ…
Impact of global structure on diffusive exploration of organelle networks
Aidan I Brown, Laura M Westrate, Elena F Koslover
We investigate diffusive search on planar networks, motivated by tubular organelle networks in cell biology that contain molecules searching for reaction partners and binding sites…
Breaking time-reversal symmetry for ratchet models of molecular machines
Arshia Zarrin, David A. Sivak, Aidan I. Brown
Biomolecular machines transduce free energy from one form to another to fulfill many important roles inside cells, with dissipation required to achieve directed progress. We invest…
Pulling cargo increases the precision of molecular motor progress
Aidan I Brown, David A Sivak
Biomolecular motors use free energy to drive a variety of cellular tasks, including the transport of cargo, such as vesicles and organelles. We find that the widely-used `constant-…
Allocating and splitting free energy to maximize molecular machine flux
Aidan I Brown, David A Sivak
Biomolecular machines transduce between different forms of energy. These machines make directed progress and increase their speed by consuming free energy, typically in the form of…
Allocating dissipation across a molecular machine cycle to maximize flux
Aidan I Brown, David A Sivak
Biomolecular machines consume free energy to break symmetry and make directed progress. Nonequilibrium ATP concentrations are the typical free energy source, with one cycle of a mo…
Toward the design principles of molecular machines
Aidan I Brown, David A Sivak
Living things avoid equilibrium using molecular machines. Such microscopic soft-matter objects encounter relatively large friction and fluctuations. We discuss design principles fo…
A model of autophagy size selectivity by receptor clustering on peroxisomes
Aidan I Brown, Andrew D Rutenberg
Selective autophagy must not only select the correct type of organelle, but also must discriminate between individual organelles of the same kind so that some but not all of the or…
Uniform spatial distribution of collagen fibril radii within tendon implies local activation of pC-collagen at individual fibrils
Andrew D Rutenberg, Aidan I Brown, Laurent Kreplak
Collagen fibril cross-sectional radii show no systematic variation between the interior and the periphery of fibril bundles, indicating an effectively constant rate of collagen inc…
Effective dissipation: breaking time-reversal symmetry in driven microscopic energy transmission
Aidan I. Brown, David A. Sivak
At molecular scales, fluctuations play a significant role and prevent biomolecular processes from always proceeding in a preferred direction, raising the question of how limited am…
Protein translocation without specific quality control in a computational model of the Tat system
Chitra R. Nayak, Aidan I. Brown, Andrew D. Rutenberg
The twin-arginine translocation (Tat) system transports folded proteins of various sizes across both bacterial and plant thylakoid membranes. The membrane-associated TatA protein i…
A storage-based model of heterocyst commitment and patterning in cyanobacteria
Aidan I Brown, Andrew D Rutenberg
When deprived of fixed nitrogen (fN), certain filamentous cyanobacteria differentiate nitrogen-fixing heterocysts. There is a large and dynamic fraction of stored fN in cyanobacter…
Heterocyst placement strategies to maximize growth of cyanobacterial filaments
Aidan I. Brown, Andrew D. Rutenberg
Under conditions of limited fixed-nitrogen, some filamentous cyanobacteria develop a regular pattern of heterocyst cells that fix nitrogen for the remaining vegetative cells. We ex…
Reconciling cyanobacterial fixed-nitrogen distributions and transport experiments with quantitative modelling
Aidan I. Brown, Andrew D. Rutenberg
Filamentous cyanobacteria growing in media with insufficient fixed nitrogen differentiate some cells into heterocysts, which fix nitrogen for the remaining vegetative cells. Transp…