4 papers
Diffusive search and trajectories on spatial networks: a propagator approach
Zubenelgenubi C. Scott, Aidan I. Brown, Saurabh S. Mogre +2
Several organelles in eukaryotic cells, including mitochondria and the endoplasmic reticulum, form interconnected tubule networks extending throughout the cell. These tubular netwo…
Theory of nonequilibrium free energy transduction by molecular machines
Aidan I Brown, David A Sivak
Biomolecular machines are protein complexes that convert between different forms of free energy. They are utilized in nature to accomplish many cellular tasks. As isothermal nonequ…
Impact of global structure on diffusive exploration of organelle networks
Aidan I Brown, Laura M Westrate, Elena F Koslover
We investigate diffusive search on planar networks, motivated by tubular organelle networks in cell biology that contain molecules searching for reaction partners and binding sites…
Breaking time-reversal symmetry for ratchet models of molecular machines
Arshia Zarrin, David A. Sivak, Aidan I. Brown
Biomolecular machines transduce free energy from one form to another to fulfill many important roles inside cells, with dissipation required to achieve directed progress. We invest…