141 citations · 294 across the 17 of their papers we have counts for
8 papers · 1 filter
Tube geometry controls protein cluster conformation and stability on the endoplasmic reticulum surface
Liam T Kischuck, Aidan I Brown
The endoplasmic reticulum (ER), a cellular organelle that forms a cell-spanning network of tubes and sheets, is an important location of protein synthesis and folding. When the ER…
Diffusive search and trajectories on spatial networks: a propagator approach
Zubenelgenubi C. Scott, Aidan I. Brown, Saurabh S. Mogre +2
Several organelles in eukaryotic cells, including mitochondria and the endoplasmic reticulum, form interconnected tubule networks extending throughout the cell. These tubular netwo…
Design principles for the glycoprotein quality control pathway
Aidan I Brown, Elena F Koslover
Newly-translated glycoproteins in the endoplasmic reticulum (ER) often undergo cycles of chaperone binding and release in order to assist in folding. Quality control is required to…
Impact of global structure on diffusive exploration of organelle networks
Aidan I Brown, Laura M Westrate, Elena F Koslover
We investigate diffusive search on planar networks, motivated by tubular organelle networks in cell biology that contain molecules searching for reaction partners and binding sites…
A model of autophagy size selectivity by receptor clustering on peroxisomes
Aidan I Brown, Andrew D Rutenberg
Selective autophagy must not only select the correct type of organelle, but also must discriminate between individual organelles of the same kind so that some but not all of the or…
A storage-based model of heterocyst commitment and patterning in cyanobacteria
Aidan I Brown, Andrew D Rutenberg
When deprived of fixed nitrogen (fN), certain filamentous cyanobacteria differentiate nitrogen-fixing heterocysts. There is a large and dynamic fraction of stored fN in cyanobacter…
Heterocyst placement strategies to maximize growth of cyanobacterial filaments
Aidan I. Brown, Andrew D. Rutenberg
Under conditions of limited fixed-nitrogen, some filamentous cyanobacteria develop a regular pattern of heterocyst cells that fix nitrogen for the remaining vegetative cells. We ex…
Reconciling cyanobacterial fixed-nitrogen distributions and transport experiments with quantitative modelling
Aidan I. Brown, Andrew D. Rutenberg
Filamentous cyanobacteria growing in media with insufficient fixed nitrogen differentiate some cells into heterocysts, which fix nitrogen for the remaining vegetative cells. Transp…