paper

Pulling cargo increases the precision of molecular motor progress

arXiv:1805.08917 · doi:10.1209/0295-5075/126/40004

Abstract

Biomolecular motors use free energy to drive a variety of cellular tasks, including the transport of cargo, such as vesicles and organelles. We find that the widely-used `constant-force' approximation for the effect of cargo on motor dynamics leads to a much larger variance of motor step number compared to explicitly modeling diffusive cargo, suggesting the constant-force approximation may be misapplied in some cases. We also find that, with cargo, motor progress is significantly more precise than suggested by a recent result. For cargo with a low relative diffusivity, the dynamics of continuous cargo motion---rather than discrete motor steps---dominate, leading to a new, more permissive bound on the precision of motor progress which is independent of the number of stages per motor cycle.

9 pages, 10 figures. This is the version of the article before peer review or editing, as submitted by an author to Europhysics Letters. IOP Publishing Ltd is not responsible for any errors or omissions in this version of the manuscript or any version derived from it. The Version of Record is available online at https://doi.org/10.1209/0295-5075/126/40004

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