The free energy cost of reducing noise while maintaining a high sensitivity

Abstract

Living systems need to be highly responsive, and also to keep fluctuations low. These goals are incompatible in equilibrium systems due to the Fluctuation Dissipation Theorem (FDT). Here, we show that biological sensory systems, driven far from equilibrium by free energy consumption, can reduce their intrinsic fluctuations while maintaining high responsiveness. By developing a continuum theory of the E. coli chemotaxis pathway, we demonstrate that adaptation can be understood as a non-equilibrium phase transition controlled by free energy dissipation, and it is characterized by a breaking of the FDT. We show that the maximum response at short time is enhanced by free energy dissipation. At the same time, the low frequency fluctuations and the adaptation error decrease with the free energy dissipation algebraically and exponentially, respectively.

References in corpus (3)

• Thermodynamic uncertainty relation for biomolecular processes
• The free energy cost of accurate biochemical oscillations
• Thermodynamic costs of information processing in sensory adaption

Cited by in corpus (24)

• Broken detailed balance and non-equilibrium dynamics in living systems
• Theory of nonequilibrium free energy transduction by molecular machines
• Improved bounds on entropy production in living systems
• Topologically protected modes in non-equilibrium stochastic systems
• Landauer in the age of synthetic biology: energy consumption and information processing in biochemical networks
• Entropy production of nano systems with timescale separation
• Thermodynamic uncertainty relation of interacting oscillators in synchrony
• Topologically-constrained fluctuations and thermodynamics regulate nonequilibrium response
• Path Weight Sampling: Exact Monte Carlo Computation of the Mutual Information between Stochastic Trajectories
• Time-reversal symmetry breaking in the chemosensory array reveals mechanisms for dissipation-enhanced cooperative sensing
• Pulling cargo increases the precision of molecular motor progress
• Design principles for biochemical oscillations with limited energy resources
• Adaptive heat engine
• Improved estimation for energy dissipation in biochemical oscillations
• Mutual Linearity is a Generic Property of Steady-State Markov Networks
• Chemotaxing E. coli do not count single molecules
• Bacterial chemotaxis: information processing, thermodynamics, and behavior
• Ultrasensitivity without conformational spread: A mechanical origin for non-equilibrium cooperativity in the bacterial flagellar motor
• Optimizing Energetic cost of Uncertainty in a Driven System With and Without Feedback
• Extracting energy from non-equilibrium fluctuations without using information
• Emergence of collective oscillations in adaptive cells
• Energy cost of dynamical stabilization: stored versus dissipated energy
• Physical Constraints on the Rhythmicity of the Biological Clock
• Noise control and utility: from regulatory network to spatial patterning