Design principles for biochemical oscillations with limited energy resources

Abstract

As biochemical systems may frequently suffer from limited energy resources so that internal molecular fluctuation has to be utilized to induce random rhythm, it is still a great theoretical challenge to understand the elementary principles for biochemical systems with limited energy resources to maintain phase accuracy and phase sensitivity. Here, we address the issue by deriving the energy accuracy and the sensitivity-accuracy trade-off relations for a general biochemical model, analytically and numerically. We find that, biochemical systems consume much lower energy cost by noise-induced oscillations to keep almost equal efficiency to maintain precise processes than that by normal oscillations, elucidating clearly the survival mechanism when energy resources are limited. Moreover, an optimal system size is predicted where both the highest sensitivity and accuracy can be reached at the same time, providing a new strategy for the design of biological networks with limited energy sources.

References in corpus (17)

• Entropy production along a stochastic trajectory and an integral fluctuation theorem
• Thermodynamic uncertainty relation for biomolecular processes
• Stochastic resonance as a collective property of ion channel assemblies
• The free energy cost of accurate biochemical oscillations
• Current fluctuations and transport efficiency for general Langevin systems
• Cost and Precision of Brownian Clocks
• Universal bound on the efficiency of molecular motors
• Uncertainty relations in stochastic processes: An information inequality approach
• Maximum likelihood and the single receptor
• Dynamics of Limit Cycle Oscillator Subject to General Noise
• Energetic costs, precision, and efficiency of a biological motor in cargo transport
• The free energy cost of reducing noise while maintaining a high sensitivity
• The complex chemical Langevin equation
• Physical limit to concentration sensing in a changing environment
• Circadian clocks optimally adapt to sunlight for reliable synchronization
• Exponential volume dependence of entropy-current fluctuations at first-order phase transitions in chemical reaction networks
• Optimal implementations for reliable circadian clocks

Cited by in corpus (8)

• Macroscopic Stochastic Thermodynamics
• Effective Entropy Production and Thermodynamic Uncertainty Relation of Active Brownian Particles
• Designing circle Swimmers: Principles and strategies
• Improved estimation for energy dissipation in biochemical oscillations
• Improving estimation of entropy production rate for run-and-tumble particle systems by high-order thermodynamic uncertainty relation
• Generalized Inverse Optimal Control and its Application in Biology
• Dissipation and fluctuations of CMOS ring oscillators close to criticality
• Universal trade-off between irreversibility and intrinsic timescale in thermal relaxation with applications to thermodynamic inference