Inferring Subsystem Efficiencies in Bipartite Molecular Machines

Abstract

Molecular machines composed of coupled subsystems transduce free energy between different external reservoirs, in the process internally transducing energy and information. While subsystem efficiencies of these molecular machines have been measured in isolation, less is known about how they behave in their natural setting when coupled together and acting in concert. Here we derive upper and lower bounds on the subsystem efficiencies of a bipartite molecular machine. We demonstrate their utility by estimating the efficiencies of the ${\mathrm{F}}_{\mathrm{o}}$ and ${\mathrm{F}}_1$ subunits of ATP synthase and that of kinesin pulling a diffusive cargo.

6 pages, 3 figures

References in corpus (6)

• Multipartite information flow for multiple Maxwell demons
• Effective rates from thermodynamically consistent coarse-graining of models for molecular motors with probe particles
• Energy and information flows in autonomous systems
• Dynamic and thermodynamic bounds for collective motor-driven transport
• Internal energy and information flows mediate input and output power in bipartite molecular machines
• Free-energy transduction within autonomous systems

Cited by in corpus (12)

• Flow of Energy and Information in Molecular Machines
• Universal bounds on the performance of information-thermodynamic engine
• Thermodynamic bounds on generalized transport: From single-molecule to bulk observables
• Unlocking the potential of information flow: Maximizing free-energy transduction in a model of an autonomous rotary molecular motor
• Information Arbitrage in Bipartite Heat Engines
• Jensen bound for the entropy production rate in stochastic thermodynamics
• Dissipation at limited resolutions: Power law and detection of hidden dissipative scales
• Waiting time distributions in hybrid models of motor-bead assays: A concept and tool for inference
• Power-Efficiency Constraint for Chemical Motors
• Active energy harvesting and work transduction by hair-cell bundles in bullfrog's inner ear
• Information thermodynamics of cellular ion pumps
• Synchronization of thermodynamically consistent stochastic phase oscillators