Multiparameter optimal control of F1-ATPase
arXiv:2410.24122 · doi:10.1103/bm3d-c67v
Abstract
Biological molecular machines convert free energy between different forms in cells, often at high efficiency. Optimal control theory provides a framework to elucidate design principles governing energetically efficient driving. Here, we use linear-response theory to design efficient protocols exercising dynamic control of trap center and stiffness in a model of driven F1-ATPase. We find that the key design principles of an efficient protocol can be satisfied either by dynamic control of both parameters or by dynamic control of a single parameter and a good static choice for the second. These results illustrate that accessing a new degree of dynamic control provides varying performance improvements in different systems.
8 main text pages, 2 appendices
References in corpus (18)
- Thermodynamic metrics and optimal paths
- Parameter Space Compression Underlies Emergent Theories and Predictive Models
- Nonequilibrium Thermodynamics of Feedback Control
- Optimal protocols and optimal transport in stochastic thermodynamics
- The geometry of thermodynamic control
- Theory of nonequilibrium free energy transduction by molecular machines
- Dynamic Riemannian Geometry of the Ising Model
- Optimal Control in Stochastic Thermodynamics
- Thermodynamic geometry of minimum-dissipation driven barrier crossing
- Near-equilibrium measurements of nonequilibrium free energy
- Nonequilibrium dissipation-free transport in F1-ATPase and the thermodynamic role of asymmetric allosterism
- Steps minimize dissipation in rapidly driven stochastic systems
- Single molecule thermodynamics of ATP synthesis by F-ATPase
- Optimal Control of Rotary Motors
- Optimal discrete control: minimizing dissipation in discretely driven nonequilibrium systems
- Flow of Energy and Information in Molecular Machines
- Optimal Control of the F-ATPase Molecular Motor
- Optimal rectification without forward-current suppression by biological molecular motor