Optimal rectification without forward-current suppression by biological molecular motor

Abstract

We experimentally showed that biological molecular motor F${}_1$-ATPase (F${}_1$) implements an optimal rectification mechanism. F${}_1$ hardly suppresses adenosine triphosphate (ATP) synthesis, which is the F${}_1$'s physiological role while inhibiting unfavorable hydrolysis of ATP. This optimal rectification is a high contrast to a simple ratchet model, where the inhibition of the backward current is inevitably accompanied by the suppression of the forward current. The detailed analysis of single-molecule trajectories demonstrated a novel but simple rectification mechanism of F${}_1$ with parallel landscapes and asymmetric transition rates.

5 pages, 5 figures + Supplementary Material (10 pages, 9 figures)

References in corpus (1)

• Thermodynamic uncertainty relation for biomolecular processes

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