3 papers
cond-mat.stat-mech2026
Optimal Control of Periodic Nonequilibrium Mechanochemical Systems via Automatic Differentiation
W. Callum Wareham, David A. Sivak
Biological molecular machines are mesoscopic systems that act repeatedly and periodically to perform important cellular tasks while contending with strong fluctuations and operatin…
physics.bio-ph2025
Efficiently driving F molecular motor in experiment by suppressing nonequilibrium variation
Takahide Mishima, Deepak Gupta, Yohei Nakayama +4
F-ATPase (F) is central to cellular energy transduction. Forcibly rotated by another motor F, F catalyzes ATP synthesis by converting mechanical work into…
physics.bio-ph2024
Multiparameter optimal control of F1-ATPase
W. Callum Wareham, David A. Sivak
Biological molecular machines convert free energy between different forms in cells, often at high efficiency. Optimal control theory provides a framework to elucidate design princi…