output
20192024
most citedPain relief devoid of opioid side effects following central action of a silylated neurotensin analog

13 citations

researchers with a paper here
collaborating institutions

4 papers

q-bio.MN2024★ 5 cited

A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new -arrestin inhibitor

Rebecca L. Brouillette, Christine E. Mona, Michael Desgagné +9

-arrestins play pivotal roles in seven transmembrane receptor (7TMR) signalling and trafficking. To study their functional role in the regulation of specific receptor systems, c…

q-bio.BM2021★ 13 cited

Metabolically Stable Neurotensin Analogs Exert Potent and Long-Acting Analgesia Without Hypothermia

Mélanie Vivancos, Roberto Fanelli, Élie Besserer-Offroy +9

The endogenous tridecapeptide neurotensin (NT) has emerged as an important inhibitory modulator of pain transmission, exerting its analgesic action through the activation of the G…

q-bio.BM2020★ 13 cited

Pain relief devoid of opioid side effects following central action of a silylated neurotensin analog

Pascal Tétreault, Élie Besserer-Offroy, Rebecca L. Brouillette +12

Neurotensin (NT) exerts naloxone-insensitive antinociceptive action through its binding to both NTS1 and NTS2 receptors and NT analogs provide stronger pain relief than morphine on…

q-bio.CB2019★ 5 cited

Label-free cell signaling pathway deconvolution of Angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIII\IV responses

Sandrine Lavenus, Élie Simard, Élie Besserer-Offroy +3

Angiotensin II (AngII) type 1 receptor (AT1R) is a G protein-coupled receptor known for its role in numerous physiological processes and its implication in many vascular diseases.…