16 citations · 34 across the 3 of their papers we have counts for
4 papers
Pain relief devoid of opioid side effects following central action of a silylated neurotensin analog
Pascal Tétreault, Élie Besserer-Offroy, Rebecca L. Brouillette +12
Neurotensin (NT) exerts naloxone-insensitive antinociceptive action through its binding to both NTS1 and NTS2 receptors and NT analogs provide stronger pain relief than morphine on…
Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain
Rebecca L. Brouillette, Élie Besserer-Offroy, Christine E. Mona +8
Pepducins are cell-penetrating, membrane-tethered lipopeptides designed to target the intracellular region of a G protein-coupled receptor (GPCR) in order to allosterically modulat…
Angiotensin II cyclic analogs as tools to investigate AT1R biased signaling mechanisms
David St-Pierre, Jérôme Cabana, Brian J. Holleran +5
G protein coupled receptors (GPCRs) produce pleiotropic effects by their capacity to engage numerous signaling pathways once activated. Functional selectivity (also called biased s…
Label-free cell signaling pathway deconvolution of Angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIII\IV responses
Sandrine Lavenus, Élie Simard, Élie Besserer-Offroy +3
Angiotensin II (AngII) type 1 receptor (AT1R) is a G protein-coupled receptor known for its role in numerous physiological processes and its implication in many vascular diseases.…