72 citations · 175 across the 8 of their papers we have counts for
8 papers
A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new -arrestin inhibitor
Rebecca L. Brouillette, Christine E. Mona, Michael Desgagné +9
-arrestins play pivotal roles in seven transmembrane receptor (7TMR) signalling and trafficking. To study their functional role in the regulation of specific receptor systems, c…
Metabolically Stable Neurotensin Analogs Exert Potent and Long-Acting Analgesia Without Hypothermia
Mélanie Vivancos, Roberto Fanelli, Élie Besserer-Offroy +9
The endogenous tridecapeptide neurotensin (NT) has emerged as an important inhibitory modulator of pain transmission, exerting its analgesic action through the activation of the G…
Pain relief devoid of opioid side effects following central action of a silylated neurotensin analog
Pascal Tétreault, Élie Besserer-Offroy, Rebecca L. Brouillette +12
Neurotensin (NT) exerts naloxone-insensitive antinociceptive action through its binding to both NTS1 and NTS2 receptors and NT analogs provide stronger pain relief than morphine on…
Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain
Rebecca L. Brouillette, Élie Besserer-Offroy, Christine E. Mona +8
Pepducins are cell-penetrating, membrane-tethered lipopeptides designed to target the intracellular region of a G protein-coupled receptor (GPCR) in order to allosterically modulat…
Angiotensin II cyclic analogs as tools to investigate AT1R biased signaling mechanisms
David St-Pierre, Jérôme Cabana, Brian J. Holleran +5
G protein coupled receptors (GPCRs) produce pleiotropic effects by their capacity to engage numerous signaling pathways once activated. Functional selectivity (also called biased s…
Label-free cell signaling pathway deconvolution of Angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIII\IV responses
Sandrine Lavenus, Élie Simard, Élie Besserer-Offroy +3
Angiotensin II (AngII) type 1 receptor (AT1R) is a G protein-coupled receptor known for its role in numerous physiological processes and its implication in many vascular diseases.…
The hypotensive effect of activated apelin receptor is correlated with \b{eta}-arrestin recruitment
Élie Besserer-Offroy, Patrick Bérubé, Jérôme Côté +8
The apelinergic system is an important player in the regulation of both vascular tone and cardiovascular function, making this physiological system an attractive target for drug de…
The signaling signature of the neurotensin type 1 receptor with endogenous ligands
Élie Besserer-Offroy, Rebecca L Brouillette, Sandrine Lavenus +8
The human neurotensin 1 receptor (hNTS1) is a G protein-coupled receptor involved in many physiological functions, including analgesia, hypothermia, and hypotension. To gain a bett…