72 citations · 108 across the 4 of their papers we have counts for
4 papers
A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new -arrestin inhibitor
Rebecca L. Brouillette, Christine E. Mona, Michael Desgagné +9
-arrestins play pivotal roles in seven transmembrane receptor (7TMR) signalling and trafficking. To study their functional role in the regulation of specific receptor systems, c…
Pain relief devoid of opioid side effects following central action of a silylated neurotensin analog
Pascal Tétreault, Élie Besserer-Offroy, Rebecca L. Brouillette +12
Neurotensin (NT) exerts naloxone-insensitive antinociceptive action through its binding to both NTS1 and NTS2 receptors and NT analogs provide stronger pain relief than morphine on…
Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain
Rebecca L. Brouillette, Élie Besserer-Offroy, Christine E. Mona +8
Pepducins are cell-penetrating, membrane-tethered lipopeptides designed to target the intracellular region of a G protein-coupled receptor (GPCR) in order to allosterically modulat…
The signaling signature of the neurotensin type 1 receptor with endogenous ligands
Élie Besserer-Offroy, Rebecca L Brouillette, Sandrine Lavenus +8
The human neurotensin 1 receptor (hNTS1) is a G protein-coupled receptor involved in many physiological functions, including analgesia, hypothermia, and hypotension. To gain a bett…