3 papers
q-bio.BM2020
Cell-penetrating pepducins targeting the neurotensin receptor type 1 relieve pain
Rebecca L. Brouillette, Élie Besserer-Offroy, Christine E. Mona +8
Pepducins are cell-penetrating, membrane-tethered lipopeptides designed to target the intracellular region of a G protein-coupled receptor (GPCR) in order to allosterically modulat…
q-bio.MN2018
The hypotensive effect of activated apelin receptor is correlated with \b{eta}-arrestin recruitment
Élie Besserer-Offroy, Patrick Bérubé, Jérôme Côté +8
The apelinergic system is an important player in the regulation of both vascular tone and cardiovascular function, making this physiological system an attractive target for drug de…
q-bio.CB2018
The signaling signature of the neurotensin type 1 receptor with endogenous ligands
Élie Besserer-Offroy, Rebecca L Brouillette, Sandrine Lavenus +8
The human neurotensin 1 receptor (hNTS1) is a G protein-coupled receptor involved in many physiological functions, including analgesia, hypothermia, and hypotension. To gain a bett…