2 citations · 4 across the 7 of their papers we have counts for
5 papers · 1 filter
How to derive a protein folding potential? A new approach to the old problem
L. A. Mirny, E. I. Shakhnovich
In this paper we introduce a novel method of deriving a pairwise potential for protein folding. The potential is obtained by optimization procedure, which simultaneously maximizes…
Theory of Kinetic Partitioning in Protein Folding (With Application to Prions)
V. I. Abkevich, A. M. Gutin, E. I. Shakhnovich
In this paper we study the phenomenon of kinetic partitioning when a polypeptide chain has two ground state conformations one of which is more kinetically reachable than the other.…
Cooperativity of Protein Folding and the Random-Field Ising Model
A. M. Gutin, V. I. Abkevich, E. I. Shakhnovich
The relation between cooperativity of protein folding and the Random-Field Ising Model (RFIM) is established. Generalization of the Imry-Ma argument predicts cooperative folding tr…
Statistical mechanics of a cross-linked polymer blend
C. D. Sfatos, A. M. Gutin, E. I. Shakhnovich
We study a blend of two kinds of homopolymers with tendency for segragation. Cross-links between the chains of different kinds do not allow macrophase separation. Instead microphas…
Design of Proteins with Specified Thermal Properties
Michael P. Morrissey, Eugene I. Shakhnovich
We propose a new and effective means for designing stable and fast-folding polypeptide sequences using a cumulant expansion of the molecular partition function. This method is uniq…