21 citations · 27 across the 13 of their papers we have counts for
3 papers · 1 filter
Emergence of mutationally robust proteins in a microscopic model of evolution
Konstantin B. Zeldovich, Eugene I. Shakhnovich
The ability to absorb mutations while retaining structure and function, or mutational robustness, is a remarkable property of natural proteins. In this Letter, we use a computation…
Identifying critical residues in protein folding: Insights from phi-value and Pfold analysis
P. F. N. Faisca, R. D. M. Travasso, R. C. Ball +1
We apply a simulational proxy of the phi-value analysis and perform extensive mutagenesis experiments to identify the nucleating residues in the folding reactions of two small latt…
Diversity against adversity: How adaptive immunity evolves potent antibodies
Muyoung Heo, Konstantin B. Zeldovich, Eugene I. Shakhnovich
How does immune system evolve functional proteins - potent antibodies - in such a short time? We address this question using a microscopic, protein-level, sequence-based model of h…