326 citations · 3k across the 112 of their papers we have counts for
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Multi-scale sequence correlations increase proteome structural disorder and promiscuity
Ariel Afek, Eugene I. Shakhnovich, David B. Lukatsky
Numerous experiments demonstrate a high level of promiscuity and structural disorder in organismal proteomes. Here we ask the question what makes a protein promiscuous, i.e., prone…
Protein abundances and interactions coevolve to promote functional complexes while suppressing non-specific binding
Muyoung Heo, Sergei Maslov, Eugene I. Shakhnovich
How do living cells achieve sufficient abundances of functional protein complexes while minimizing promiscuous non-functional interactions? Here we study this problem using a first…
Sequence correlations shape protein promiscuity
David B. Lukatsky, Ariel Afek, Eugene I. Shakhnovich
We predict analytically that diagonal correlations of amino acid positions within protein sequences statistically enhance protein propensity for nonspecific binding. We use the ter…
Optimality of mutation and selection in germinal centers
Jingshan Zhang, Eugene I. Shakhnovich
The population dynamics theory of B cells in a typical germinal center could play an important role in revealing how affinity maturation is achieved. However, the existing models e…