21 citations · 27 across the 13 of their papers we have counts for
3 papers · 1 filter
Emergence of clonal selection and affinity maturation in an ab initio microscopic model of immunity
Muyoung Heo, Konstantin B. Zeldovich, Eugene I. Shakhnovich
Mechanisms of immunity, and of the host-pathogen interactions in general are among the most fundamental problems of medicine, ecology, and evolution studies. Here, we present a mic…
The Hypercube of Life: How Protein Stability Imposes Limits on Organism Complexity and Speed of Molecular Evolution
Konstantin Zeldovich, Peiqiu Chen, Eugene Shakhnovich
Classical population genetics a priori assigns fitness to alleles without considering molecular or functional properties of proteins that these alleles encode. Here we study popula…
DNA unzipping phase diagram calculated via replica theory
C. Brian Roland, Kristi Adamson Hatch, Mara Prentiss +1
We show how single-molecule unzipping experiments can provide strong evidence that the zero-force melting transition of long molecules of natural dsDNA should be classified as a ph…