2 citations · 4 across the 7 of their papers we have counts for
5 papers · 1 filter
Of sequence and structure: Strategies of protein thermostability in evolutionary perspective
Igor N. Berezovsky, Eugene I. Shakhnovich
In this work we employ various methods of analysis (unfolding simulations and comparative analysis of structures and sequences of proteomes of thermophilic organisms) to show that…
Semiconservative replication in the quasispecies model II: Generalization to arbitrary lesion repair probabilities
Emmanuel Tannenbaum, James L. Sherley, Eugene I. Shakhnovich
This paper extends the semiconservative quasispecies equations to account for arbitrary post-replication lesion repair efficiency. Such an extension could be an important tool for…
Imperfect DNA Repair and the Error Catastrophe
Yisroel Brumer, Emmanuel Tannenbaum, Eugene I. Shakhnovich
In this Letter, we extend the semiconservative quasispecies equations to incorporate imperfect DNA lesion repair. We study the equilibrium behavior of this model in the limit of in…
Protein Structure and Evolutionary History Determine Sequence Space Topology
Boris Shakhnovich, Eric Deeds, Charles Delisi +1
Understanding the observed variability in the number of homologs of a gene is a very important, unsolved problem that has broad implications for research into co-evolution of struc…
An Exact Model of Fluctuations in Gene Expression
William W. Chen, Jeremy L. England, Eugene I. Shakhnovich
Fluctuations in the measured mRNA levels of unperturbed cells under fixed conditions have often been viewed as an impediment to the extraction of information from expression profil…