Positronium imaging with the novel multiphoton PET scanner

Abstract

In vivo assessment of cancer and precise location of altered tissues at initial stages of molecular disorders are important diagnostic challenges. Positronium is copiously formed in the free molecular spaces in the patient's body during positron emission tomography (PET). The positronium properties vary according to the size of inter- and intramolecular voids and the concentration of molecules in them such as, e.g., molecular oxygen, O2; therefore, positronium imaging may provide information about disease progression during the initial stages of molecular alterations. Current PET systems do not allow acquisition of positronium images. This study presents a new method that enables positronium imaging by simultaneous registration of annihilation photons and deexcitation photons from pharmaceuticals labeled with radionuclides. The first positronium imaging of a phantom built from cardiac myxoma and adipose tissue is demonstrated. It is anticipated that positronium imaging will substantially enhance the specificity of PET diagnostics.

10 pages, 5 figures

References in corpus (14)

• Test of a single module of the J-PET scanner based on plastic scintillators
• Positronium imaging with the novel multiphoton PET scanner
• Feasibility study of the positronium imaging with the J-PET tomograph
• J-PET: a new technology for the whole-body PET imaging
• A novel method for the line-of-response and time-of-flight reconstruction in TOF-PET detectors based on a library of synchronized model signals
• Evaluation of Single-Chip, Real-Time Tomographic Data Processing on FPGA - SoC Devices
• Multichannel FPGA based MVT system for high precision time (20~ps~RMS) and charge measurement
• Feasibility studies of the polarization of photons beyond the optical wavelength regime with the J-PET detector
• Human Tissues Investigation Using PALS Technique
• J-PET Framework: Software platform for PET tomography data reconstruction and analysis
• Synchronisation and calibration of the 24-modules J-PET prototype with 300~mm axial field of view
• Studies of unicellular micro-organisms Saccharomyces cerevisiae by means of Positron Annihilation Lifetime Spectroscopy
• Commissioning of the J-PET detector in view of the positron annihilation lifetime spectroscopy
• Potential for biomedical applications of Positron Annihilation Lifetime Spectroscopy (PALS)

Cited by in corpus (19)

• Positronium imaging with the novel multiphoton PET scanner
• Positronium Physics and Biomedical Applications
• Discrete symmetries tested at 10${}^{-4}$ precision using linear polarization of photons from positronium annihilations
• Multi-photon time-of-flight MLEM application for the positronium imaging in J-PET
• Decoherence puzzle in measurements of photons originating from electron-positron annihilation
• Comparative studies of plastic scintillator strips with high technical attenuation length for the total-body J-PET scanner
• New opportunities for kaonic atoms measurements from CdZnTe detectors
• Measurements of high-n transitions in intermediate mass kaonic atoms by SIDDHARTA-2 at DA$\mathrm{\Phi }$NE
• Ortho-positronium Lifetime For Soft-tissue Classification
• J-PET detection modules based on plastic scintillators for performing studies with positron and positronium beams
• An analytic, moment-based method to estimate orthopositronium lifetimes in positron annihilation lifetime spectroscopy measurements
• TOF MLEM Adaptation for the Total-Body J-PET with a Realistic Analytical System Response Matrix
• Development of the normalization method for the Jagiellonian PET scanner
• First Positronium Lifetime Imaging using ${}^{52}$Mn and ${}^{55}$Co with a plastic-based PET scanner
• Quantum Error Channels in High Energetic Photonic Systems
• Development of the front-end electronics for a cost-effective PET-like detector system
• Quantum Entanglement Degree, Mean Positronium Lifetime, and the $3\gamma$/$2\gamma$ Annihilation-Rate Ratio as Novel PET Biomarkers for Hypoxia -- Concept, Challenges, and Predictions
• Quantifying Quantum Correlations in Annihilation Photon Pairs under Compton Scattering
• First tests of the full SIDDHARTA-2 experimental apparatus with a 4 He gaseous target