4.8k citations
- European Bioinformatics InstituteGB18 papers
- University of CambridgeGB14 papers
- The Gurdon InstituteGB10 papers
- University College LondonGB9 papers
- Centre National de la Recherche ScientifiqueFR6 papers
- Wellcome / EPSRC Centre for Interventional and Surgical SciencesGB6 papers
- InsermFR3 papers
- Institute of Science and Technology AustriaAT3 papers
- Institut national de recherche en sciences et technologies du numériqueFR3 papers
- National Center for Tumor DiseasesDE3 papers
- SIB Swiss Institute of BioinformaticsCH3 papers
- Wellcome/MRC Cambridge Stem Cell InstituteGB3 papers
6 papers · 1 filter
SBML Qualitative Models: a model representation format and infrastructure to foster interactions between qualitative modelling formalisms and tools
Claudine Chaouiya, Duncan Berenguier, Sarah M Keating +21
Background: Qualitative frameworks, especially those based on the logical discrete formalism, are increasingly used to model regulatory and signalling networks. A major advantage o…
Genome-wide inference of ancestral recombination graphs
Matthew D. Rasmussen, Melissa J. Hubisz, Ilan Gronau +1
The complex correlation structure of a collection of orthologous DNA sequences is uniquely captured by the "ancestral recombination graph" (ARG), a complete record of coalescence a…
Bayesian Test for Colocalisation Between Pairs of Genetic Association Studies Using Summary Statistics
Claudia Giambartolomei, Damjan Vukcevic, Eric E. Schadt +4
Genetic association studies, in particular the genome-wide association study design, have provided a wealth of novel insights into the aetiology of a wide range of human diseases a…
A Unifying Model of Genome Evolution Under Parsimony
Benedict Paten, Daniel R. Zerbino, Glenn Hickey +1
We present a data structure called a history graph that offers a practical basis for the analysis of genome evolution. It conceptually simplifies the study of parsimonious evolutio…
Statistical testing of shared genetic control for potentially related traits
Chris Wallace
Integration of data from genome-wide single nucleotide polymorphism (SNP) association studies of different traits should allow researchers to disentangle the genetics of potentiall…
Assemblathon 2: evaluating de novo methods of genome assembly in three vertebrate species
Keith R. Bradnam, Joseph N. Fass, Anton Alexandrov +88
Background - The process of generating raw genome sequence data continues to become cheaper, faster, and more accurate. However, assembly of such data into high-quality, finished g…