445 citations
- University of California, Santa BarbaraUS6 papers
- Max Planck Institute for Intelligent SystemsDE5 papers
- Kavli Institute for Theoretical PhysicsUS4 papers
- Max Planck SocietyDE4 papers
- Karolinska InstitutetSE3 papers
- Karolinska University HospitalSE3 papers
- Stanford UniversityUS3 papers
- Centre National de la Recherche ScientifiqueFR2 papers
- Los Alamos National LaboratoryUS2 papers
- Stockholm South General HospitalSE2 papers
- University of CambridgeGB2 papers
- University of TübingenDE2 papers
8 papers · 1 filter
Genealogies of rapidly adapting populations
Richard A. Neher, Oskar Hallatschek
The genetic diversity of a species is shaped by its recent evolutionary history and can be used to infer demographic events or selective sweeps. Most inference methods are based on…
FFPopSim: An efficient forward simulation package for the evolution of large populations
Fabio Zanini, Richard A. Neher
The analysis of the evolutionary dynamics of a population with many polymorphic loci is challenging since a large number of possible genotypes needs to be tracked. In the absence o…
Mathematical modeling of escape of HIV from cytotoxic T lymphocyte responses
Vitaly V. Ganusov, Richard A. Neher, Alan S. Perelson
Human immunodeficiency virus (HIV-1 or simply HIV) induces a persistent infection, which in the absence of treatment leads to AIDS and death in almost all infected individuals. HIV…
Fluctuations of fitness distributions and the rate of Muller's ratchet
Richard A. Neher, Boris I. Shraiman
The accumulation of deleterious mutations is driven by rare fluctuations which lead to the loss of all mutation free individuals, a process known as Muller's ratchet. Even though M…
Estimating the Strength of Selective Sweeps from Deep Population Diversity Data
Philipp W. Messer, Richard A. Neher
Selective sweeps are typically associated with a local reduction of genetic diversity around the adaptive site. However, selective sweeps can also quickly carry neutral mutations t…
LMM-Lasso: A Lasso Multi-Marker Mixed Model for Association Mapping with Population Structure Correction
Barbara Rakitsch, Christoph Lippert, Oliver Stegle +1
Exploring the genetic basis of heritable traits remains one of the central challenges in biomedical research. In simple cases, single polymorphic loci explain a significant fractio…