3 papers
q-bio.PE2016
Establishment and stability of the latent HIV-1 DNA reservoir
Johanna Brodin, Fabio Zanini, Lina Thebo +4
HIV-1 infection currently cannot be cured because the virus persists as integrated proviral DNA in long-lived cells despite years of suppressive antiretroviral therapy (ART). To ch…
q-bio.PE2016
In-vivo mutation rates and fitness landscape of HIV-1
Fabio Zanini, Vadim Puller, Johanna Brodin +2
Mutation rates and fitness costs of deleterious mutations are difficult to measure in vivo but essential for a quantitative understanding of evolution. Using whole genome deep sequ…
q-bio.PE2015
Population genomics of intrapatient HIV-1 evolution
Fabio Zanini, Johanna Brodin, Lina Thebo +4
Many microbial populations rapidly adapt to changing environments with multiple variants competing for survival. To quantify such complex evolutionary dynamics in vivo, time resolv…