209 citations · 497 across the 8 of their papers we have counts for
8 papers
Challenges in cybersecurity: Lessons from biological defense systems
Edward Schrom, Ann Kinzig, Stephanie Forrest +18
We explore the commonalities between methods for assuring the security of computer systems (cybersecurity) and the mechanisms that have evolved through natural selection to protect…
Quantification of Ebola virus replication kinetics in vitro
Laura E. Liao, Jonathan Carruthers, Sophie J. Smither +13
Mathematical modelling has successfully been used to provide quantitative descriptions of many viral infections, but for the Ebola virus, which requires biosafety level 4 facilitie…
Regulation of T cell expansion by antigen presentation dynamics
Andreas Mayer, Yaojun Zhang, Alan S. Perelson +1
An essential feature of the adaptive immune system is the proliferation of antigen-specific lymphocytes during an immune reaction to form a large pool of effector cells. This proli…
Inferring HIV escape rates from multi-locus genotype data
Taylor A. Kessinger, Alan S. Perelson, Richard A. Neher
Cytotoxic T-lymphocytes (CTLs) recognize viral protein fragments displayed by major histocompatibility complex (MHC) molecules on the surface of virally infected cells and generate…
Mathematical modeling of escape of HIV from cytotoxic T lymphocyte responses
Vitaly V. Ganusov, Richard A. Neher, Alan S. Perelson
Human immunodeficiency virus (HIV-1 or simply HIV) induces a persistent infection, which in the absence of treatment leads to AIDS and death in almost all infected individuals. HIV…
Agent-Based Modeling of Host-Pathogen Systems: The Successes and Challenges
Amy L. Bauer, Catherine A. A. Beauchemin, Alan S. Perelson
Agent-based models have been employed to describe numerous processes in immunology. Simulations based on these types of models have been used to enhance our understanding of immuno…
Opportunistic infection as a cause of transient viremia in chronically infected HIV patients under treatment with HAART
Laura E. Jones, Alan S. Perelson
When highly active antiretroviral therapy is administered for long periods of time to HIV-1 infected patients, most patients achieve viral loads that are ``undetectable'' by standa…
A Cayley Tree Immune Network Model with Antibody Dynamics
Russell W. Anderson, Avidan U. Neumann, Alan S. Perelson
A Cayley tree model of idiotypic networks that includes both B cell and antibody dynamics is formulated and analyzed. As in models with B cells only, localized states exist in the…