209 citations · 497 across the 8 of their papers we have counts for
4 papers · 1 filter
Regulation of T cell expansion by antigen presentation dynamics
Andreas Mayer, Yaojun Zhang, Alan S. Perelson +1
An essential feature of the adaptive immune system is the proliferation of antigen-specific lymphocytes during an immune reaction to form a large pool of effector cells. This proli…
Inferring HIV escape rates from multi-locus genotype data
Taylor A. Kessinger, Alan S. Perelson, Richard A. Neher
Cytotoxic T-lymphocytes (CTLs) recognize viral protein fragments displayed by major histocompatibility complex (MHC) molecules on the surface of virally infected cells and generate…
Mathematical modeling of escape of HIV from cytotoxic T lymphocyte responses
Vitaly V. Ganusov, Richard A. Neher, Alan S. Perelson
Human immunodeficiency virus (HIV-1 or simply HIV) induces a persistent infection, which in the absence of treatment leads to AIDS and death in almost all infected individuals. HIV…
Opportunistic infection as a cause of transient viremia in chronically infected HIV patients under treatment with HAART
Laura E. Jones, Alan S. Perelson
When highly active antiretroviral therapy is administered for long periods of time to HIV-1 infected patients, most patients achieve viral loads that are ``undetectable'' by standa…