445 citations
- University of California, Santa BarbaraUS6 papers
- Max Planck Institute for Intelligent SystemsDE5 papers
- Kavli Institute for Theoretical PhysicsUS4 papers
- Max Planck SocietyDE4 papers
- Karolinska InstitutetSE3 papers
- Karolinska University HospitalSE3 papers
- Stanford UniversityUS3 papers
- Centre National de la Recherche ScientifiqueFR2 papers
- Los Alamos National LaboratoryUS2 papers
- Stockholm South General HospitalSE2 papers
- University of CambridgeGB2 papers
- University of TübingenDE2 papers
26 papers
Population-specific design of de-immunized protein biotherapeutics
Benjamin Schubert, Charlotta Schärfe, Pierre Dönnes +3
Immunogenicity is a major problem during the development of biotherapeutics since it can lead to rapid clearance of the drug and adverse reactions. The challenge for biotherapeutic…
Establishment and stability of the latent HIV-1 DNA reservoir
Johanna Brodin, Fabio Zanini, Lina Thebo +4
HIV-1 infection currently cannot be cured because the virus persists as integrated proviral DNA in long-lived cells despite years of suppressive antiretroviral therapy (ART). To ch…
In-vivo mutation rates and fitness landscape of HIV-1
Fabio Zanini, Vadim Puller, Johanna Brodin +2
Mutation rates and fitness costs of deleterious mutations are difficult to measure in vivo but essential for a quantitative understanding of evolution. Using whole genome deep sequ…
Prediction, dynamics, and visualization of antigenic phenotypes of seasonal influenza viruses
Richard A. Neher, Trevor Bedford, Rodney S. Daniels +2
Human seasonal influenza viruses evolve rapidly, enabling the virus population to evade immunity and re-infect previously infected individuals. Antigenic properties are largely det…
Population genomics of intrapatient HIV-1 evolution
Fabio Zanini, Johanna Brodin, Lina Thebo +4
Many microbial populations rapidly adapt to changing environments with multiple variants competing for survival. To quantify such complex evolutionary dynamics in vivo, time resolv…
High contrast imaging of reversibly switchable fluorescent proteins via temporally unmixed Multispectral Optoacoustic Tomography (tuMSOT)
Andre C Stiel, X Luis Dean-Ben, Yuanyuan Jiang +3
Photocontrol of reversibly switchable fluorescent proteins (RSFPs) was used to program optoacoustic signal time courses that were temporally unmixed to increase the proteins contra…