148 citations · 1k across the 43 of their papers we have counts for
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Three-Dimensional Loop Extrusion
Andrea Bonato, Davide Michieletto
Loop extrusion convincingly describes how certain Structural Maintenance of Chromosome (SMC) proteins mediate the formation of large DNA loops. Yet, most of the existing computatio…
Dynamic and Facilitated Binding of Topoisomerase Accelerates Topological Relaxation
Davide Michieletto, Yair Fosado, Elias Melas +3
How type 2 Topoisomerase (TopoII) proteins relax and simplify the topology of DNA molecules is one of the most intriguing open questions in biophysics. Most of the existing models…
DNA topology dictates strength and flocculation in DNA-microtubule composites
Karthik R. Peddireddy, Davide Michieletto, Gina Aguirre +3
Polymer composites are ubiquitous in biology and industry alike, owing to their emergent desirable mechanical properties not attainable in single-species systems. At the same time,…